E3 ubiquitin-protein ligase MARCHF2 (MARCHF2)
Homo sapiens — UniProt Q9P0N8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase MARCHF2 (MARCHF2) is a protein from Homo sapiens identified by UniProt accession Q9P0N8, 246 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q9P0N8; gene symbol MARCHF2.
- Organism: Homo sapiens.
- Length: 246 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin concentration and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF2 |
|---|---|
| UniProt accession | Q9P0N8 |
| Gene | MARCHF2 |
| Organism | Homo sapiens |
| Length | 246 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.28
- high density lipoprotein cholesterol measurement · score 0.22
- appendicular lean mass · score 0.20
- mean corpuscular hemoglobin · score 0.17
- hypertension · score 0.16
- cardiovascular disease · score 0.11
- waist-hip ratio · score 0.10
- apolipoprotein A 1 measurement · score 0.09
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0N8-F1 | alphafold | PREDICTED | 71.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0N8.
Amino-acid sequence (246 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARCHF2?
The strongest Open Targets associations for MARCHF2 are mean corpuscular volume, mean corpuscular hemoglobin concentration, high density lipoprotein cholesterol measurement, appendicular lean mass and mean corpuscular hemoglobin.
How long is the MARCHF2 protein?
The Homo sapiens MARCHF2 protein (UniProt Q9P0N8) is 246 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0N8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0N8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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