TBC1 domain family member 7 (TBC1D7)
Homo sapiens — UniProt Q9P0N9
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 7 (TBC1D7) is a protein from Homo sapiens identified by UniProt accession Q9P0N9, 293 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9P0N9; gene symbol TBC1D7.
- Organism: Homo sapiens.
- Length: 293 amino acids.
- Top disease associations (Open Targets): macrocephaly/megalencephaly syndrome, autosomal recessive, developmental and epileptic encephalopathy and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 7 |
|---|---|
| UniProt accession | Q9P0N9 |
| Gene | TBC1D7 |
| Organism | Homo sapiens |
| Length | 293 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- macrocephaly/megalencephaly syndrome, autosomal recessive · score 0.58
- developmental and epileptic encephalopathy · score 0.49
- neurodegenerative disease · score 0.46
- isolated megalencephaly · score 0.37
- Macrocephaly · score 0.34
- mathematical ability · score 0.26
- self reported educational attainment · score 0.26
- basophil percentage of leukocytes · score 0.12
- basophil count · score 0.11
- body mass index · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0N9-F1 | alphafold | PREDICTED | 92.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0N9.
Amino-acid sequence (293 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D7?
The strongest Open Targets associations for TBC1D7 are macrocephaly/megalencephaly syndrome, autosomal recessive, developmental and epileptic encephalopathy, neurodegenerative disease, isolated megalencephaly and Macrocephaly.
How long is the TBC1D7 protein?
The Homo sapiens TBC1D7 protein (UniProt Q9P0N9) is 293 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0N9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0N9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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