E3 ubiquitin-protein ligase RNF181 (RNF181)
Homo sapiens — UniProt Q9P0P0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF181 (RNF181) is a protein from Homo sapiens identified by UniProt accession Q9P0P0, 153 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9P0P0; gene symbol RNF181.
- Organism: Homo sapiens.
- Length: 153 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, body height and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF181 |
|---|---|
| UniProt accession | Q9P0P0 |
| Gene | RNF181 |
| Organism | Homo sapiens |
| Length | 153 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.21
- body height · score 0.17
- lean body mass · score 0.16
- myeloid white cell count · score 0.10
- lymphocyte count · score 0.10
- fat body mass · score 0.10
- appendicular lean mass · score 0.09
- coronary artery disease · score 0.09
- leukocyte count · score 0.09
- eosinophil count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0P0-F1 | alphafold | PREDICTED | 84.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0P0.
Amino-acid sequence (153 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF181?
The strongest Open Targets associations for RNF181 are serum gamma-glutamyl transferase measurement, body height, lean body mass, myeloid white cell count and lymphocyte count.
How long is the RNF181 protein?
The Homo sapiens RNF181 protein (UniProt Q9P0P0) is 153 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0P0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0P0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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