Transmembrane protein 14C (TMEM14C)
Homo sapiens — UniProt Q9P0S9
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 14C (TMEM14C) is a protein from Homo sapiens identified by UniProt accession Q9P0S9, 112 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q9P0S9; gene symbol TMEM14C.
- Organism: Homo sapiens.
- Length: 112 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 14C |
|---|---|
| UniProt accession | Q9P0S9 |
| Gene | TMEM14C |
| Organism | Homo sapiens |
| Length | 112 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.30
- mean corpuscular hemoglobin · score 0.25
- mean corpuscular hemoglobin concentration · score 0.24
- Blackfan-Diamond anemia · score 0.07
- hemoglobin D disease · score 0.05
- dominant beta-thalassemia · score 0.05
- hemoglobin H disease · score 0.04
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.04
- hemoglobin E disease · score 0.04
- dehydrated hereditary stomatocytosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0S9-F1 | alphafold | PREDICTED | 62.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0S9.
Amino-acid sequence (112 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM14C?
The strongest Open Targets associations for TMEM14C are mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, Blackfan-Diamond anemia and hemoglobin D disease.
How long is the TMEM14C protein?
The Homo sapiens TMEM14C protein (UniProt Q9P0S9) is 112 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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