Sentrin-specific protease 1 (SENP1)
Homo sapiens — UniProt Q9P0U3
Data last refreshed: (UniProt release unknown)
Key facts
Sentrin-specific protease 1 (SENP1) is a protein from Homo sapiens identified by UniProt accession Q9P0U3, 644 residues long. MolForge cross-references it against 0 known binders and 227 disease associations.
- UniProt accession: Q9P0U3; gene symbol SENP1.
- Organism: Homo sapiens.
- Length: 644 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pancreatic adenocarcinoma and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sentrin-specific protease 1 |
|---|---|
| UniProt accession | Q9P0U3 |
| Gene | SENP1 |
| Organism | Homo sapiens |
| Length | 644 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (227)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- pancreatic adenocarcinoma · score 0.22
- hematocrit · score 0.22
- reticulocyte count · score 0.21
- reticulocyte measurement · score 0.21
- mean corpuscular volume · score 0.20
- breast adenocarcinoma · score 0.18
- hemoglobin measurement · score 0.16
- vital capacity · score 0.15
- smoking status measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0U3-F1 | alphafold | PREDICTED | 60.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0U3.
Amino-acid sequence (644 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SENP1?
The strongest Open Targets associations for SENP1 are neurodegenerative disease, pancreatic adenocarcinoma, hematocrit, reticulocyte count and reticulocyte measurement.
How long is the SENP1 protein?
The Homo sapiens SENP1 protein (UniProt Q9P0U3) is 644 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0U3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0U3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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