Spermatogenesis-associated protein 7 (SPATA7)
Homo sapiens — UniProt Q9P0W8
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 7 (SPATA7) is a protein from Homo sapiens identified by UniProt accession Q9P0W8, 599 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9P0W8; gene symbol SPATA7.
- Organism: Homo sapiens.
- Length: 599 amino acids.
- Top disease associations (Open Targets): Leber congenital amaurosis, retinitis pigmentosa and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 7 |
|---|---|
| UniProt accession | Q9P0W8 |
| Gene | SPATA7 |
| Organism | Homo sapiens |
| Length | 599 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- Leber congenital amaurosis · score 0.75
- retinitis pigmentosa · score 0.60
- Retinal dystrophy · score 0.51
- retinitis pigmentosa 94, variable age at onset · score 0.50
- severe early-childhood-onset retinal dystrophy · score 0.38
- Posterior column ataxia - retinitis pigmentosa · score 0.37
- creatinine measurement · score 0.35
- glomerular filtration rate · score 0.35
- autosomal recessive retinitis pigmentosa · score 0.33
- Krabbe disease · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0W8-F1 | alphafold | PREDICTED | 57.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0W8.
Amino-acid sequence (599 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA7?
The strongest Open Targets associations for SPATA7 are Leber congenital amaurosis, retinitis pigmentosa, Retinal dystrophy, retinitis pigmentosa 94, variable age at onset and severe early-childhood-onset retinal dystrophy.
How long is the SPATA7 protein?
The Homo sapiens SPATA7 protein (UniProt Q9P0W8) is 599 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0W8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0W8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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