Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)
Homo sapiens — UniProt Q9P0X4
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) is a protein from Homo sapiens identified by UniProt accession Q9P0X4, 2223 residues long. MolForge cross-references it against 4 known binders and 87 disease associations.
- UniProt accession: Q9P0X4; gene symbol CACNA1I.
- Organism: Homo sapiens.
- Length: 2223 amino acids.
- Approved drugs acting on it (DrugCentral): Pimozide and Flunarizine.
- Top disease associations (Open Targets): epilepsy, schizophrenia and cardiovascular disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent T-type calcium channel subunit alpha-1I |
|---|---|
| UniProt accession | Q9P0X4 |
| Gene | CACNA1I |
| Organism | Homo sapiens |
| Length | 2223 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (87)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.59
- schizophrenia · score 0.53
- cardiovascular disease · score 0.50
- self reported educational attainment · score 0.46
- Seizure · score 0.43
- autism spectrum disorder · score 0.42
- intelligence · score 0.42
- Tourette syndrome · score 0.39
- generalized anxiety disorder · score 0.39
- gastrointestinal disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P0X4-F1 | alphafold | PREDICTED | 59.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P0X4.
Amino-acid sequence (2223 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target CACNA1I?
DrugCentral lists 2 approved drugs whose mechanism of action is CACNA1I: Pimozide and Flunarizine.
Which diseases are associated with CACNA1I?
The strongest Open Targets associations for CACNA1I are epilepsy, schizophrenia, cardiovascular disease, self reported educational attainment and Seizure.
How long is the CACNA1I protein?
The Homo sapiens CACNA1I protein (UniProt Q9P0X4) is 2223 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P0X4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P0X4 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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