Vacuolar protein sorting-associated protein 54 (VPS54)
Homo sapiens — UniProt Q9P1Q0
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 54 (VPS54) is a protein from Homo sapiens identified by UniProt accession Q9P1Q0, 977 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q9P1Q0; gene symbol VPS54.
- Organism: Homo sapiens.
- Length: 977 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, wellbeing measurement and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 54 |
|---|---|
| UniProt accession | Q9P1Q0 |
| Gene | VPS54 |
| Organism | Homo sapiens |
| Length | 977 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- wellbeing measurement · score 0.32
- neuroticism measurement · score 0.29
- mathematical ability · score 0.28
- diastolic blood pressure · score 0.22
- depressive symptom measurement · score 0.13
- tooth agenesis · score 0.11
- body height · score 0.04
- Charcot-Marie-Tooth disease axonal type 2Z · score 0.04
- sunburn · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1Q0-F1 | alphafold | PREDICTED | 74.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1Q0.
Amino-acid sequence (977 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS54?
The strongest Open Targets associations for VPS54 are neurodegenerative disease, wellbeing measurement, neuroticism measurement, mathematical ability and diastolic blood pressure.
How long is the VPS54 protein?
The Homo sapiens VPS54 protein (UniProt Q9P1Q0) is 977 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1Q0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1Q0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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