DNA-directed RNA polymerase I subunit RPA12 (POLR1H)
Homo sapiens — UniProt Q9P1U0
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase I subunit RPA12 (POLR1H) is a protein from Homo sapiens identified by UniProt accession Q9P1U0, 126 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q9P1U0; gene symbol POLR1H.
- Organism: Homo sapiens.
- Length: 126 amino acids.
- Top disease associations (Open Targets): lymphocyte count, lipid measurement and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase I subunit RPA12 |
|---|---|
| UniProt accession | Q9P1U0 |
| Gene | POLR1H |
| Organism | Homo sapiens |
| Length | 126 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.13
- lipid measurement · score 0.13
- mean corpuscular hemoglobin · score 0.12
- hepatocellular carcinoma · score 0.09
- breast cancer · score 0.08
- Varicose veins · score 0.08
- neoplasm · score 0.07
- Takayasu arteritis · score 0.07
- late-onset myasthenia gravis · score 0.07
- head and neck squamous cell carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1U0-F1 | alphafold | PREDICTED | 79.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1U0.
Amino-acid sequence (126 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR1H?
The strongest Open Targets associations for POLR1H are lymphocyte count, lipid measurement, mean corpuscular hemoglobin, hepatocellular carcinoma and breast cancer.
How long is the POLR1H protein?
The Homo sapiens POLR1H protein (UniProt Q9P1U0) is 126 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1U0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1U0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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