Osmosensitive cation channel TMEM63C (TMEM63C)
Homo sapiens — UniProt Q9P1W3
Data last refreshed: (UniProt release unknown)
Key facts
Osmosensitive cation channel TMEM63C (TMEM63C) is a protein from Homo sapiens identified by UniProt accession Q9P1W3, 806 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q9P1W3; gene symbol TMEM63C.
- Organism: Homo sapiens.
- Length: 806 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): hereditary spastic paraplegia, leukemia and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Osmosensitive cation channel TMEM63C |
|---|---|
| UniProt accession | Q9P1W3 |
| Gene | TMEM63C |
| Organism | Homo sapiens |
| Length | 806 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- hereditary spastic paraplegia · score 0.51
- leukemia · score 0.37
- mathematical ability · score 0.33
- smoking behavior · score 0.20
- body fat percentage · score 0.07
- body mass index · score 0.06
- monocyte count · score 0.05
- fat body mass · score 0.04
- lean body mass · score 0.04
- atrial fibrillation · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1W3-F1 | alphafold | PREDICTED | 74.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1W3.
Amino-acid sequence (806 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM63C?
The strongest Open Targets associations for TMEM63C are hereditary spastic paraplegia, leukemia, mathematical ability, smoking behavior and body fat percentage.
How long is the TMEM63C protein?
The Homo sapiens TMEM63C protein (UniProt Q9P1W3) is 806 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1W3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1W3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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