Serine/threonine-protein kinase pim-2 (PIM2)
Homo sapiens — UniProt Q9P1W9
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase pim-2 (PIM2) is a protein from Homo sapiens identified by UniProt accession Q9P1W9, 311 residues long. MolForge cross-references it against 4 known binders and 129 disease associations.
- UniProt accession: Q9P1W9; gene symbol PIM2.
- Organism: Homo sapiens.
- Length: 311 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Miyoshi myopathy and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase pim-2 |
|---|---|
| UniProt accession | Q9P1W9 |
| Gene | PIM2 |
| Organism | Homo sapiens |
| Length | 311 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (129)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- Miyoshi myopathy · score 0.10
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
- cancer · score 0.09
- acute myeloid leukemia · score 0.08
- breast cancer · score 0.08
- colorectal neoplasm · score 0.07
- myelodysplastic syndrome · score 0.07
- multiple myeloma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1W9-F1 | alphafold | PREDICTED | 89.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1W9.
Amino-acid sequence (311 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIM2?
The strongest Open Targets associations for PIM2 are neurodegenerative disease, Miyoshi myopathy, neoplasm, hepatocellular carcinoma and cancer.
How long is the PIM2 protein?
The Homo sapiens PIM2 protein (UniProt Q9P1W9) is 311 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1W9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1W9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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