PHD and RING finger domain-containing protein 1 (PHRF1)
Homo sapiens — UniProt Q9P1Y6
Data last refreshed: (UniProt release unknown)
Key facts
PHD and RING finger domain-containing protein 1 (PHRF1) is a protein from Homo sapiens identified by UniProt accession Q9P1Y6, 1649 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q9P1Y6; gene symbol PHRF1.
- Organism: Homo sapiens.
- Length: 1649 amino acids.
- Top disease associations (Open Targets): hypothyroidism, Abnormality of refraction and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PHD and RING finger domain-containing protein 1 |
|---|---|
| UniProt accession | Q9P1Y6 |
| Gene | PHRF1 |
| Organism | Homo sapiens |
| Length | 1649 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.18
- Abnormality of refraction · score 0.18
- systemic lupus erythematosus · score 0.18
- Mental deterioration · score 0.14
- myxedema · score 0.12
- Aganglionic megacolon · score 0.11
- Hirschsprung disease · score 0.11
- high density lipoprotein cholesterol measurement · score 0.10
- systemic scleroderma · score 0.07
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1Y6-F1 | alphafold | PREDICTED | 45.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1Y6.
Amino-acid sequence (1649 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHRF1?
The strongest Open Targets associations for PHRF1 are hypothyroidism, Abnormality of refraction, systemic lupus erythematosus, Mental deterioration and myxedema.
How long is the PHRF1 protein?
The Homo sapiens PHRF1 protein (UniProt Q9P1Y6) is 1649 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1Y6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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