Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3)
Homo sapiens — UniProt Q9P1Z3
Data last refreshed: (UniProt release unknown)
Key facts
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) is a protein from Homo sapiens identified by UniProt accession Q9P1Z3, 774 residues long. MolForge cross-references it against 2 known binders and 111 disease associations.
- UniProt accession: Q9P1Z3; gene symbol HCN3.
- Organism: Homo sapiens.
- Length: 774 amino acids.
- Approved drugs acting on it (DrugCentral): Ivabradine and Dronedarone.
- Top disease associations (Open Targets): pyruvate kinase deficiency of red cells, Red cell distribution width and squamous cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 |
|---|---|
| UniProt accession | Q9P1Z3 |
| Gene | HCN3 |
| Organism | Homo sapiens |
| Length | 774 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (111)
Diseases linked to this target (Open Targets).
- pyruvate kinase deficiency of red cells · score 0.18
- Red cell distribution width · score 0.16
- squamous cell lung carcinoma · score 0.13
- cutaneous melanoma · score 0.12
- HbA1c measurement · score 0.09
- Crohn's disease · score 0.09
- Romano-Ward syndrome · score 0.08
- hepatocellular carcinoma · score 0.08
- familial atrial fibrillation · score 0.07
- Familial short QT syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P1Z3-F1 | alphafold | PREDICTED | 72.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P1Z3.
Amino-acid sequence (774 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target HCN3?
DrugCentral lists 2 approved drugs whose mechanism of action is HCN3: Ivabradine and Dronedarone.
Which diseases are associated with HCN3?
The strongest Open Targets associations for HCN3 are pyruvate kinase deficiency of red cells, Red cell distribution width, squamous cell lung carcinoma, cutaneous melanoma and HbA1c measurement.
How long is the HCN3 protein?
The Homo sapiens HCN3 protein (UniProt Q9P1Z3) is 774 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P1Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P1Z3 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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