E3 ubiquitin-protein ligase HECW2 (HECW2)

Homo sapiens — UniProt Q9P2P5

Gene: HECW2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

E3 ubiquitin-protein ligase HECW2 (HECW2) is a protein from Homo sapiens identified by UniProt accession Q9P2P5, 1572 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

UniProt accession: Q9P2P5; gene symbol HECW2.
Organism: Homo sapiens.
Length: 1572 amino acids.
Top disease associations (Open Targets): neurodevelopmental disorder with hypotonia, seizures, and absent language, genetic disorder and heel bone mineral density.
3D structure: AlphaFold model available.

Target properties

Protein name	E3 ubiquitin-protein ligase HECW2
UniProt accession	Q9P2P5
Gene	HECW2
Organism	Homo sapiens
Length	1572 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with hypotonia, seizures, and absent language · score 0.75
genetic disorder · score 0.51
heel bone mineral density · score 0.43
Neurodevelopmental disorder · score 0.38
complex neurodevelopmental disorder · score 0.37
neurodegenerative disease · score 0.37
blood phosphate measurement · score 0.30
chronotype measurement · score 0.29
BMI-adjusted waist-hip ratio · score 0.29
Abnormality of the nervous system · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2P5-F1	alphafold	PREDICTED	60.42	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P2P5.

Amino-acid sequence (1572 residues)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ IVWRIEPGPY FMEPEIKICF KYYHGISGAL RATTPCITVK NPAVMMGAEG MEGGASGNLH SRKLVSFTLS DLRAVGLKKG MFFNPDPYLK MSIQPGKKSS FPTCAHHGQE RRSTIISNTT NPIWHREKYS FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAIGDQMLS YNLGRRLPAD HVSGYLQFKV EVTSSVHEDA SPEAVGTILG VNSVNGDLGS PSDDEDMPGS HHDSQVCSNG PVSEDSAADG TPKHSFRTSS TLEIDTEELT STSSRTSPPR GRQDSLNDYL DAIEHNGHSR PGTATCSERS MGASPKLRSS FPTDTRLNAM LHIDSDEEDH EFQQDLGYPS SLEEEGGLIM FSRASRADDG SLTSQTKLED NPVENEEAST HEAASFEDKP ENLPELAESS LPAGPAPEEG EGGPEPQPSA DQGSAELCGS QEVDQPTSGA DTGTSDASGG SRRAVSETES LDQGSEPSQV SSETEPSDPA RTESVSEAST RPEGESDLEC ADSSCNESVT TQLSSVDTRC SSLESARFPE TPAFSSQEEE DGACAAEPTS SGPAEGSQES VCTAGSLPVV QVPSGEDEGP GAESATVPDQ EELGEVWQRR GSLEGAAAAA ESPPQEEGSA GEAQGTCEGA TAQEEGATGG SQANGHQPLR SLPSVRQDVS RYQRVDEALP PNWEARIDSH GRIFYVDHVN RTTTWQRPTA PPAPQVLQRS NSIQQMEQLN RRYQSIRRTM TNERPEENTN AIDGAGEEAD FHQASADFRR ENILPHSTSR SRITLLLQSP PVKFLISPEF FTVLHSNPSA YRMFTNNTCL KHMITKVRRD THHFERYQHN RDLVGFLNMF ANKQLELPRG WEMKHDHQGK AFFVDHNSRT TTFIDPRLPL QSSRPTSALV HRQHLTRQRS HSAGEVGEDS RHAGPPVLPR PSSTFNTVSR PQYQDMVPVA YNDKIVAFLR QPNIFEILQE RQPDLTRNHS LREKIQFIRT EGTPGLVRLS SDADLVMLLS LFEEEIMSYV PPHALLHPSY CQSPRGSPVS SPQNSPGTQR ANARAPAPYK RDFEAKLRNF YRKLETKGYG QGPGKLKLII RRDHLLEDAF NQIMGYSRKD LQRNKLYVTF VGEEGLDYSG PSREFFFLVS RELFNPYYGL FEYSANDTYT VQISPMSAFV DNHHEWFRFS GRILGLALIH QYLLDAFFTR PFYKALLRIL CDLSDLEYLD EEFHQSLQWM KDNDIHDILD LTFTVNEEVF GQITERELKP GGANIPVTEK NKKEYIERMV KWRIERGVVQ QTESLVRGFY EVVDARLVSV FDARELELVI AGTAEIDLSD WRNNTEYRGG YHDNHIVIRW FWAAVERFNN EQRLRLLQFV TGTSSIPYEG FASLRGSNGP RRFCVEKWGK ITALPRAHTC FNRLDLPPYP SFSMLYEKLL TAVEETSTFG LE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with HECW2?

The strongest Open Targets associations for HECW2 are neurodevelopmental disorder with hypotonia, seizures, and absent language, genetic disorder, heel bone mineral density, Neurodevelopmental disorder and complex neurodevelopmental disorder.

How long is the HECW2 protein?

The Homo sapiens HECW2 protein (UniProt Q9P2P5) is 1572 amino acids long.

Browse: Targets: H · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9P2P5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9P2P5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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