Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (LRIT1)
Homo sapiens — UniProt Q9P2V4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (LRIT1) is a protein from Homo sapiens identified by UniProt accession Q9P2V4, 623 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.
- UniProt accession: Q9P2V4; gene symbol LRIT1.
- Organism: Homo sapiens.
- Length: 623 amino acids.
- Top disease associations (Open Targets): Myopia, refractive error and age at onset.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 |
|---|---|
| UniProt accession | Q9P2V4 |
| Gene | LRIT1 |
| Organism | Homo sapiens |
| Length | 623 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (166)
Diseases linked to this target (Open Targets).
- Myopia · score 0.13
- refractive error · score 0.10
- age at onset · score 0.10
- refractive error measurement · score 0.09
- influenza A (H1N1) · score 0.08
- pulmonary arterial hypertension · score 0.08
- neurofibrillary tangles measurement · score 0.07
- Miyoshi myopathy · score 0.07
- Abnormality of refraction · score 0.07
- infection · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9P2V4-F1 | alphafold | PREDICTED | 73.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9P2V4.
Amino-acid sequence (623 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRIT1?
The strongest Open Targets associations for LRIT1 are Myopia, refractive error, age at onset, refractive error measurement and influenza A (H1N1).
How long is the LRIT1 protein?
The Homo sapiens LRIT1 protein (UniProt Q9P2V4) is 623 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9P2V4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9P2V4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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