DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Homo sapiens — UniProt Q9UBC3
Data last refreshed: (UniProt release unknown)
Key facts
DNA (cytosine-5)-methyltransferase 3B (DNMT3B) is a protein from Homo sapiens identified by UniProt accession Q9UBC3, 853 residues long. MolForge cross-references it against 2 known binders and 554 disease associations.
- UniProt accession: Q9UBC3; gene symbol DNMT3B.
- Organism: Homo sapiens.
- Length: 853 amino acids.
- Top disease associations (Open Targets): ICF syndrome, immunodeficiency-centromeric instability-facial anomalies syndrome and facioscapulohumeral muscular dystrophy 4, digenic.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA (cytosine-5)-methyltransferase 3B |
|---|---|
| UniProt accession | Q9UBC3 |
| Gene | DNMT3B |
| Organism | Homo sapiens |
| Length | 853 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (554)
Diseases linked to this target (Open Targets).
- ICF syndrome · score 0.84
- immunodeficiency-centromeric instability-facial anomalies syndrome · score 0.55
- facioscapulohumeral muscular dystrophy 4, digenic · score 0.53
- neurodegenerative disease · score 0.52
- cancer · score 0.39
- lymphocyte count · score 0.39
- Facioscapulohumeral dystrophy · score 0.38
- melanoma · score 0.38
- breast carcinoma · score 0.37
- brain measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBC3-F1 | alphafold | PREDICTED | 72.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBC3.
Amino-acid sequence (853 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNMT3B?
The strongest Open Targets associations for DNMT3B are ICF syndrome, immunodeficiency-centromeric instability-facial anomalies syndrome, facioscapulohumeral muscular dystrophy 4, digenic, neurodegenerative disease and cancer.
How long is the DNMT3B protein?
The Homo sapiens DNMT3B protein (UniProt Q9UBC3) is 853 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBC3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBC3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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