SUMO-activating enzyme subunit 1 (SAE1)
Homo sapiens — UniProt Q9UBE0
Data last refreshed: (UniProt release unknown)
Key facts
SUMO-activating enzyme subunit 1 (SAE1) is a protein from Homo sapiens identified by UniProt accession Q9UBE0, 346 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q9UBE0; gene symbol SAE1.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lymphocyte count and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SUMO-activating enzyme subunit 1 |
|---|---|
| UniProt accession | Q9UBE0 |
| Gene | SAE1 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- lymphocyte count · score 0.30
- lysosomal storage disease · score 0.29
- monocyte count · score 0.24
- lymphocyte percentage of leukocytes · score 0.22
- neutrophil percentage of leukocytes · score 0.21
- erythrocyte count · score 0.19
- ovarian cancer · score 0.18
- endometrial cancer · score 0.18
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBE0-F1 | alphafold | PREDICTED | 91.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBE0.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAE1?
The strongest Open Targets associations for SAE1 are neurodegenerative disease, lymphocyte count, lysosomal storage disease, monocyte count and lymphocyte percentage of leukocytes.
How long is the SAE1 protein?
The Homo sapiens SAE1 protein (UniProt Q9UBE0) is 346 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBE0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBE0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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