Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)
Homo sapiens — UniProt Q9UBI6
Data last refreshed: (UniProt release unknown)
Key facts
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12) is a protein from Homo sapiens identified by UniProt accession Q9UBI6, 72 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9UBI6; gene symbol GNG12.
- Organism: Homo sapiens.
- Length: 72 amino acids.
- Top disease associations (Open Targets): calcium measurement, neuroticism measurement and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 |
|---|---|
| UniProt accession | Q9UBI6 |
| Gene | GNG12 |
| Organism | Homo sapiens |
| Length | 72 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.39
- neuroticism measurement · score 0.36
- mean corpuscular hemoglobin concentration · score 0.28
- head and neck squamous cell carcinoma · score 0.26
- Red cell distribution width · score 0.24
- lymphocyte count · score 0.23
- lung adenocarcinoma · score 0.23
- mean platelet volume · score 0.23
- mean corpuscular volume · score 0.23
- mean corpuscular hemoglobin · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBI6-F1 | alphafold | PREDICTED | 89.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBI6.
Amino-acid sequence (72 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GNG12?
The strongest Open Targets associations for GNG12 are calcium measurement, neuroticism measurement, mean corpuscular hemoglobin concentration, head and neck squamous cell carcinoma and Red cell distribution width.
How long is the GNG12 protein?
The Homo sapiens GNG12 protein (UniProt Q9UBI6) is 72 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBI6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBI6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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