Headcase protein homolog (HECA)
Homo sapiens — UniProt Q9UBI9
Data last refreshed: (UniProt release unknown)
Key facts
Headcase protein homolog (HECA) is a protein from Homo sapiens identified by UniProt accession Q9UBI9, 543 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9UBI9; gene symbol HECA.
- Organism: Homo sapiens.
- Length: 543 amino acids.
- Top disease associations (Open Targets): congenital heart disease, hepatocellular carcinoma and cholesterol-ester transfer protein deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Headcase protein homolog |
|---|---|
| UniProt accession | Q9UBI9 |
| Gene | HECA |
| Organism | Homo sapiens |
| Length | 543 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- congenital heart disease · score 0.07
- hepatocellular carcinoma · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.05
- hypertriglyceridemia 2 · score 0.05
- neoplasm · score 0.04
- Combined hyperlipidemia · score 0.04
- thyroid hormone metabolism, abnormal, 2 · score 0.04
- sitosterolemia · score 0.04
- homozygous familial hypercholesterolemia · score 0.04
- glycogen storage disease VI · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBI9-F1 | alphafold | PREDICTED | 66.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBI9.
Amino-acid sequence (543 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HECA?
The strongest Open Targets associations for HECA are congenital heart disease, hepatocellular carcinoma, cholesterol-ester transfer protein deficiency, hypertriglyceridemia 2 and neoplasm.
How long is the HECA protein?
The Homo sapiens HECA protein (UniProt Q9UBI9) is 543 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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