P2X purinoceptor 2 (P2RX2)
Homo sapiens — UniProt Q9UBL9
Data last refreshed: (UniProt release unknown)
Key facts
P2X purinoceptor 2 (P2RX2) is a protein from Homo sapiens identified by UniProt accession Q9UBL9, 471 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9UBL9; gene symbol P2RX2.
- Organism: Homo sapiens.
- Length: 471 amino acids.
- Top disease associations (Open Targets): deafness, autosomal dominant nonsyndromic hearing loss and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | P2X purinoceptor 2 |
|---|---|
| UniProt accession | Q9UBL9 |
| Gene | P2RX2 |
| Organism | Homo sapiens |
| Length | 471 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- deafness · score 0.55
- autosomal dominant nonsyndromic hearing loss · score 0.54
- mean corpuscular volume · score 0.25
- erythrocyte count · score 0.23
- mean corpuscular hemoglobin concentration · score 0.21
- nonsyndromic genetic hearing loss · score 0.18
- mean reticulocyte volume · score 0.18
- Sensorineural hearing impairment · score 0.12
- Red cell distribution width · score 0.11
- cutaneous melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBL9-F1 | alphafold | PREDICTED | 79.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBL9.
Amino-acid sequence (471 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with P2RX2?
The strongest Open Targets associations for P2RX2 are deafness, autosomal dominant nonsyndromic hearing loss, mean corpuscular volume, erythrocyte count and mean corpuscular hemoglobin concentration.
How long is the P2RX2 protein?
The Homo sapiens P2RX2 protein (UniProt Q9UBL9) is 471 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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