About Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) is a protein
from Homo sapiens identified by UniProt accession
Q9UBM8, 478 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C |
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| UniProt accession | Q9UBM8 |
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| Gene | MGAT4C |
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| Organism | Homo sapiens |
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| Length | 478 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- antisocial behaviour measurement · score 0.32
- attention deficit hyperactivity disorder · score 0.32
- substance abuse · score 0.32
- hair color · score 0.17
- diabetic nephropathy · score 0.17
- schizophrenia · score 0.17
- type 2 diabetes mellitus · score 0.17
- hair colour measurement · score 0.16
- mathematical ability · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBM8-F1 | alphafold | PREDICTED | 87.15 | — |
Amino-acid sequence (478 residues)
MFKFHQMKHI FEILDKMRCL RKRSTVSFLG VLVIFLLFMN LYIEDSYVLE GDKQLIRETS THQLNSERYV HTFKDLSNFS GAINVTYRYL AATPLQRKRY LTIGLSSVKR KKGNYLLETI KSIFEQSSYE ELKEISVVVH LADFNSSWRD AMVQDITQKF AHHIIAGRLM VIHAPEEYYP ILDGLKRNYN DPEDRVKFRS KQNVDYAFLL NFCANTSDYY VMLEDDVRCS KNFLTAIKKV IASLEGTYWV TLEFSKLGYI GKLYHSHDLP RLAHFLLMFY QEMPCDWLLT HFRGLLAQKN VIRFKPSLFQ HMGYYSSYKG TENKLKDDDF EEESFDIPDN PPASLYTNMN VFENYEASKA YSSVDEYFWG KPPSTGDVFV IVFENPIIIK KIKVNTGTED RQNDILHHGA LDVGENVMPS KQRRQCSTYL RLGEFKNGNF EMSGVNQKIP FDIHCMRIYV TKTQKEWLII RSISIWTS
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