Exostosin-like 2 (EXTL2)
Homo sapiens — UniProt Q9UBQ6
Data last refreshed: (UniProt release unknown)
Key facts
Exostosin-like 2 (EXTL2) is a protein from Homo sapiens identified by UniProt accession Q9UBQ6, 330 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9UBQ6; gene symbol EXTL2.
- Organism: Homo sapiens.
- Length: 330 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, lymphocyte count and lymphocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exostosin-like 2 |
|---|---|
| UniProt accession | Q9UBQ6 |
| Gene | EXTL2 |
| Organism | Homo sapiens |
| Length | 330 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.28
- lymphocyte count · score 0.28
- lymphocyte percentage of leukocytes · score 0.27
- sum of eosinophil and basophil counts · score 0.21
- neutrophil percentage of granulocytes · score 0.21
- eosinophil count · score 0.20
- reticulocyte count · score 0.14
- reticulocyte measurement · score 0.12
- eosinophil percentage of leukocytes · score 0.11
- neutrophil percentage of leukocytes · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBQ6-F1 | alphafold | PREDICTED | 88.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBQ6.
Amino-acid sequence (330 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXTL2?
The strongest Open Targets associations for EXTL2 are multiple sclerosis, lymphocyte count, lymphocyte percentage of leukocytes, sum of eosinophil and basophil counts and neutrophil percentage of granulocytes.
How long is the EXTL2 protein?
The Homo sapiens EXTL2 protein (UniProt Q9UBQ6) is 330 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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