Ribosomal protein S6 kinase beta-2 (RPS6KB2)
Homo sapiens — UniProt Q9UBS0
Data last refreshed: (UniProt release unknown)
Key facts
Ribosomal protein S6 kinase beta-2 (RPS6KB2) is a protein from Homo sapiens identified by UniProt accession Q9UBS0, 482 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q9UBS0; gene symbol RPS6KB2.
- Organism: Homo sapiens.
- Length: 482 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin and mean reticulocyte volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosomal protein S6 kinase beta-2 |
|---|---|
| UniProt accession | Q9UBS0 |
| Gene | RPS6KB2 |
| Organism | Homo sapiens |
| Length | 482 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.44
- mean corpuscular hemoglobin · score 0.38
- mean reticulocyte volume · score 0.35
- mean corpuscular hemoglobin concentration · score 0.30
- thyroid gland adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.28
- ovarian cancer · score 0.28
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- erythrocyte count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBS0-F1 | alphafold | PREDICTED | 75.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBS0.
Amino-acid sequence (482 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPS6KB2?
The strongest Open Targets associations for RPS6KB2 are mean corpuscular volume, mean corpuscular hemoglobin, mean reticulocyte volume, mean corpuscular hemoglobin concentration and thyroid gland adenocarcinoma.
How long is the RPS6KB2 protein?
The Homo sapiens RPS6KB2 protein (UniProt Q9UBS0) is 482 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBS0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBS0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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