DnaJ homolog subfamily B member 11 (DNAJB11)
Homo sapiens — UniProt Q9UBS4
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily B member 11 (DNAJB11) is a protein from Homo sapiens identified by UniProt accession Q9UBS4, 358 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q9UBS4; gene symbol DNAJB11.
- Organism: Homo sapiens.
- Length: 358 amino acids.
- Top disease associations (Open Targets): polycystic kidney disease 6 with or without polycystic liver disease, Autosomal dominant polycystic kidney disease and Polycystic Kidney Disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily B member 11 |
|---|---|
| UniProt accession | Q9UBS4 |
| Gene | DNAJB11 |
| Organism | Homo sapiens |
| Length | 358 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- polycystic kidney disease 6 with or without polycystic liver disease · score 0.72
- Autosomal dominant polycystic kidney disease · score 0.61
- Polycystic Kidney Disease · score 0.55
- Cystic Kidney Disease · score 0.46
- familial juvenile hyperuricemic nephropathy · score 0.46
- stage 5 chronic kidney disease · score 0.46
- genetic disorder · score 0.41
- Renal cyst · score 0.34
- Meckel syndrome · score 0.34
- Multiple renal cysts · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBS4-F1 | alphafold | PREDICTED | 84.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBS4.
Amino-acid sequence (358 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJB11?
The strongest Open Targets associations for DNAJB11 are polycystic kidney disease 6 with or without polycystic liver disease, Autosomal dominant polycystic kidney disease, Polycystic Kidney Disease, Cystic Kidney Disease and familial juvenile hyperuricemic nephropathy.
How long is the DNAJB11 protein?
The Homo sapiens DNAJB11 protein (UniProt Q9UBS4) is 358 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBS4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBS4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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