E3 ubiquitin-protein ligase RNF14 (RNF14)
Homo sapiens — UniProt Q9UBS8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF14 (RNF14) is a protein from Homo sapiens identified by UniProt accession Q9UBS8, 474 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9UBS8; gene symbol RNF14.
- Organism: Homo sapiens.
- Length: 474 amino acids.
- Top disease associations (Open Targets): clear cell renal carcinoma, drug use measurement and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF14 |
|---|---|
| UniProt accession | Q9UBS8 |
| Gene | RNF14 |
| Organism | Homo sapiens |
| Length | 474 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- drug use measurement · score 0.08
- reticulocyte count · score 0.08
- serum gamma-glutamyl transferase measurement · score 0.07
- DNA methylation · score 0.05
- metabolite measurement · score 0.05
- reticulocyte measurement · score 0.03
- pulse pressure measurement · score 0.03
- cancer · score 0.01
- Abnormal sperm morphology · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UBS8-F1 | alphafold | PREDICTED | 82.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UBS8.
Amino-acid sequence (474 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF14?
The strongest Open Targets associations for RNF14 are clear cell renal carcinoma, drug use measurement, reticulocyte count, serum gamma-glutamyl transferase measurement and DNA methylation.
How long is the RNF14 protein?
The Homo sapiens RNF14 protein (UniProt Q9UBS8) is 474 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UBS8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UBS8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.