tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1)
Homo sapiens — UniProt Q9UET6
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) is a protein from Homo sapiens identified by UniProt accession Q9UET6, 329 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9UET6; gene symbol FTSJ1.
- Organism: Homo sapiens.
- Length: 329 amino acids.
- Top disease associations (Open Targets): X-linked non-syndromic intellectual disability, genetic disorder and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase |
|---|---|
| UniProt accession | Q9UET6 |
| Gene | FTSJ1 |
| Organism | Homo sapiens |
| Length | 329 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.71
- genetic disorder · score 0.50
- Intellectual disability · score 0.37
- X-linked complex neurodevelopmental disorder · score 0.37
- autism spectrum disorder · score 0.12
- non-small cell lung carcinoma · score 0.08
- neoplasm · score 0.07
- triple-negative breast cancer · score 0.07
- X-linked retinal dysplasia · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UET6-F1 | alphafold | PREDICTED | 84.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UET6.
Amino-acid sequence (329 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FTSJ1?
The strongest Open Targets associations for FTSJ1 are X-linked non-syndromic intellectual disability, genetic disorder, Intellectual disability, X-linked complex neurodevelopmental disorder and autism spectrum disorder.
How long is the FTSJ1 protein?
The Homo sapiens FTSJ1 protein (UniProt Q9UET6) is 329 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UET6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UET6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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