STE20/SPS1-related proline-alanine-rich protein kinase (STK39)
Homo sapiens — UniProt Q9UEW8
Data last refreshed: (UniProt release unknown)
Key facts
STE20/SPS1-related proline-alanine-rich protein kinase (STK39) is a protein from Homo sapiens identified by UniProt accession Q9UEW8, 545 residues long. MolForge cross-references it against 5 known binders and 370 disease associations.
- UniProt accession: Q9UEW8; gene symbol STK39.
- Organism: Homo sapiens.
- Length: 545 amino acids.
- Target class: Kinase.
- Top disease associations (Open Targets): Parkinson disease, lean body mass and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | STE20/SPS1-related proline-alanine-rich protein kinase |
|---|---|
| UniProt accession | Q9UEW8 |
| Gene | STK39 |
| Organism | Homo sapiens |
| Length | 545 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (370)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.45
- lean body mass · score 0.42
- body mass index · score 0.41
- body height · score 0.37
- body weight · score 0.34
- prostate carcinoma · score 0.32
- monocyte count · score 0.31
- diffuse plaque measurement · score 0.30
- brain volume measurement · score 0.29
- base metabolic rate measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UEW8-F1 | alphafold | PREDICTED | 75.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UEW8.
Amino-acid sequence (545 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STK39?
The strongest Open Targets associations for STK39 are Parkinson disease, lean body mass, body mass index, body height and body weight.
How long is the STK39 protein?
The Homo sapiens STK39 protein (UniProt Q9UEW8) is 545 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UEW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UEW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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