Gamma-adducin (ADD3)
Homo sapiens — UniProt Q9UEY8
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-adducin (ADD3) is a protein from Homo sapiens identified by UniProt accession Q9UEY8, 706 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q9UEY8; gene symbol ADD3.
- Organism: Homo sapiens.
- Length: 706 amino acids.
- Top disease associations (Open Targets): Inherited congenital spastic tetraplegia, self reported educational attainment and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-adducin |
|---|---|
| UniProt accession | Q9UEY8 |
| Gene | ADD3 |
| Organism | Homo sapiens |
| Length | 706 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- Inherited congenital spastic tetraplegia · score 0.62
- self reported educational attainment · score 0.43
- eosinophil count · score 0.40
- cerebral palsy · score 0.33
- bipolar disorder · score 0.33
- adolescent idiopathic scoliosis · score 0.32
- FEV/FVC ratio · score 0.30
- platelet crit · score 0.27
- Abnormality of refraction · score 0.25
- hair colour measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UEY8-F1 | alphafold | PREDICTED | 66.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UEY8.
Amino-acid sequence (706 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADD3?
The strongest Open Targets associations for ADD3 are Inherited congenital spastic tetraplegia, self reported educational attainment, eosinophil count, cerebral palsy and bipolar disorder.
How long is the ADD3 protein?
The Homo sapiens ADD3 protein (UniProt Q9UEY8) is 706 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UEY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UEY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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