Voltage-dependent calcium channel gamma-5 subunit (CACNG5)
Homo sapiens — UniProt Q9UF02
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent calcium channel gamma-5 subunit (CACNG5) is a protein from Homo sapiens identified by UniProt accession Q9UF02, 275 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9UF02; gene symbol CACNG5.
- Organism: Homo sapiens.
- Length: 275 amino acids.
- Top disease associations (Open Targets): cardiovascular disease, generalized anxiety disorder and Polyuria.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent calcium channel gamma-5 subunit |
|---|---|
| UniProt accession | Q9UF02 |
| Gene | CACNG5 |
| Organism | Homo sapiens |
| Length | 275 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.46
- generalized anxiety disorder · score 0.39
- Polyuria · score 0.37
- Urinary incontinence · score 0.37
- gastrointestinal disease · score 0.37
- insomnia · score 0.34
- total blood protein measurement · score 0.32
- Epstein Barr viral capsid antigen seropositivity · score 0.31
- anxiety · score 0.27
- breast adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UF02-F1 | alphafold | PREDICTED | 73.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UF02.
Amino-acid sequence (275 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CACNG5?
The strongest Open Targets associations for CACNG5 are cardiovascular disease, generalized anxiety disorder, Polyuria, Urinary incontinence and gastrointestinal disease.
How long is the CACNG5 protein?
The Homo sapiens CACNG5 protein (UniProt Q9UF02) is 275 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UF02 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UF02 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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