Pleckstrin homology domain-containing family B member 1 (PLEKHB1)
Homo sapiens — UniProt Q9UF11
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family B member 1 (PLEKHB1) is a protein from Homo sapiens identified by UniProt accession Q9UF11, 243 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9UF11; gene symbol PLEKHB1.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, Barrett's esophagus and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family B member 1 |
|---|---|
| UniProt accession | Q9UF11 |
| Gene | PLEKHB1 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.34
- Barrett's esophagus · score 0.05
- blood protein measurement · score 0.05
- esophageal adenocarcinoma · score 0.05
- brain measurement · score 0.04
- cortical thickness · score 0.03
- insomnia measurement · score 0.03
- medulloblastoma · score 0.03
- atypical teratoid rhabdoid tumor · score 0.02
- platelet count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UF11-F1 | alphafold | PREDICTED | 63.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UF11.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHB1?
The strongest Open Targets associations for PLEKHB1 are cortical surface area measurement, Barrett's esophagus, blood protein measurement, esophageal adenocarcinoma and brain measurement.
How long is the PLEKHB1 protein?
The Homo sapiens PLEKHB1 protein (UniProt Q9UF11) is 243 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UF11 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UF11 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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