Hydroxyproline dehydrogenase (PRODH2)
Homo sapiens — UniProt Q9UF12
Data last refreshed: (UniProt release unknown)
Key facts
Hydroxyproline dehydrogenase (PRODH2) is a protein from Homo sapiens identified by UniProt accession Q9UF12, 460 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9UF12; gene symbol PRODH2.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Top disease associations (Open Targets): seizures-intellectual disability due to hydroxylysinuria syndrome, hyperdibasic aminoaciduria type 1 and carnosinemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hydroxyproline dehydrogenase |
|---|---|
| UniProt accession | Q9UF12 |
| Gene | PRODH2 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- seizures-intellectual disability due to hydroxylysinuria syndrome · score 0.06
- hyperdibasic aminoaciduria type 1 · score 0.05
- carnosinemia · score 0.05
- cystinuria · score 0.05
- iminoglycinuria · score 0.05
- hyperprolinemia type 2 · score 0.05
- primary hyperoxaluria type 3 · score 0.05
- saccharopinuria · score 0.05
- hyperprolinemia type 1 · score 0.05
- primary hyperoxaluria type 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UF12-F1 | alphafold | PREDICTED | 87.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UF12.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRODH2?
The strongest Open Targets associations for PRODH2 are seizures-intellectual disability due to hydroxylysinuria syndrome, hyperdibasic aminoaciduria type 1, carnosinemia, cystinuria and iminoglycinuria.
How long is the PRODH2 protein?
The Homo sapiens PRODH2 protein (UniProt Q9UF12) is 460 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UF12 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UF12 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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