Ephrin type-A receptor 6 (EPHA6)
Homo sapiens — UniProt Q9UF33
Data last refreshed: (UniProt release unknown)
Key facts
Ephrin type-A receptor 6 (EPHA6) is a protein from Homo sapiens identified by UniProt accession Q9UF33, 1036 residues long. MolForge cross-references it against 14 known binders and 128 disease associations.
- UniProt accession: Q9UF33; gene symbol EPHA6.
- Organism: Homo sapiens.
- Length: 1036 amino acids.
- Approved drugs acting on it (DrugCentral): Vandetanib.
- Top disease associations (Open Targets): medullary thyroid gland carcinoma, thyroid cancer and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ephrin type-A receptor 6 |
|---|---|
| UniProt accession | Q9UF33 |
| Gene | EPHA6 |
| Organism | Homo sapiens |
| Length | 1036 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (128)
Diseases linked to this target (Open Targets).
- medullary thyroid gland carcinoma · score 0.48
- thyroid cancer · score 0.47
- neoplasm · score 0.41
- thyroid carcinoma · score 0.39
- thyroid neoplasm · score 0.39
- non-small cell lung carcinoma · score 0.38
- neurodegenerative disease · score 0.36
- lung cancer · score 0.30
- systolic blood pressure · score 0.24
- head and neck squamous cell carcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UF33-F1 | alphafold | PREDICTED | 78.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UF33.
Amino-acid sequence (1036 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target EPHA6?
DrugCentral lists 1 approved drug whose mechanism of action is EPHA6: Vandetanib.
Which diseases are associated with EPHA6?
The strongest Open Targets associations for EPHA6 are medullary thyroid gland carcinoma, thyroid cancer, neoplasm, thyroid carcinoma and thyroid neoplasm.
How long is the EPHA6 protein?
The Homo sapiens EPHA6 protein (UniProt Q9UF33) is 1036 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UF33 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UF33 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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