Neuronal-specific septin-3 (SEPTIN3)
Homo sapiens — UniProt Q9UH03
Data last refreshed: (UniProt release unknown)
Key facts
Neuronal-specific septin-3 (SEPTIN3) is a protein from Homo sapiens identified by UniProt accession Q9UH03, 358 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q9UH03; gene symbol SEPTIN3.
- Organism: Homo sapiens.
- Length: 358 amino acids.
- Top disease associations (Open Targets): triple-negative breast cancer, unipolar depression and response to selective serotonin reuptake inhibitor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Neuronal-specific septin-3 |
|---|---|
| UniProt accession | Q9UH03 |
| Gene | SEPTIN3 |
| Organism | Homo sapiens |
| Length | 358 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- triple-negative breast cancer · score 0.09
- unipolar depression · score 0.06
- response to selective serotonin reuptake inhibitor · score 0.05
- body weight · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.04
- schizophrenia · score 0.04
- pseudohypoparathyroidism type 2 · score 0.03
- Familial isolated hypoparathyroidism · score 0.03
- autism spectrum disorder · score 0.03
- bipolar disorder · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UH03-F1 | alphafold | PREDICTED | 81.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UH03.
Amino-acid sequence (358 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEPTIN3?
The strongest Open Targets associations for SEPTIN3 are triple-negative breast cancer, unipolar depression, response to selective serotonin reuptake inhibitor, body weight and hypoparathyroidism, familial isolated, 2.
How long is the SEPTIN3 protein?
The Homo sapiens SEPTIN3 protein (UniProt Q9UH03) is 358 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UH03 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UH03 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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