DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)
Homo sapiens — UniProt Q9UH17
Data last refreshed: (UniProt release unknown)
Key facts
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) is a protein from Homo sapiens identified by UniProt accession Q9UH17, 382 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.
- UniProt accession: Q9UH17; gene symbol APOBEC3B.
- Organism: Homo sapiens.
- Length: 382 amino acids.
- Top disease associations (Open Targets): colon adenocarcinoma, gastrointestinal stromal tumor and Endometrial Endometrioid Adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA dC->dU-editing enzyme APOBEC-3B |
|---|---|
| UniProt accession | Q9UH17 |
| Gene | APOBEC3B |
| Organism | Homo sapiens |
| Length | 382 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (244)
Diseases linked to this target (Open Targets).
- colon adenocarcinoma · score 0.37
- gastrointestinal stromal tumor · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- breast carcinoma · score 0.32
- cutaneous melanoma · score 0.31
- hepatocellular carcinoma · score 0.29
- head and neck squamous cell carcinoma · score 0.29
- melanoma · score 0.29
- acute myeloid leukemia · score 0.29
- urinary bladder carcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UH17-F1 | alphafold | PREDICTED | 87.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UH17.
Amino-acid sequence (382 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APOBEC3B?
The strongest Open Targets associations for APOBEC3B are colon adenocarcinoma, gastrointestinal stromal tumor, Endometrial Endometrioid Adenocarcinoma, breast carcinoma and cutaneous melanoma.
How long is the APOBEC3B protein?
The Homo sapiens APOBEC3B protein (UniProt Q9UH17) is 382 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UH17 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UH17 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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