Kelch-like protein 3 (KLHL3)
Homo sapiens — UniProt Q9UH77
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 3 (KLHL3) is a protein from Homo sapiens identified by UniProt accession Q9UH77, 587 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.
- UniProt accession: Q9UH77; gene symbol KLHL3.
- Organism: Homo sapiens.
- Length: 587 amino acids.
- Top disease associations (Open Targets): pseudohypoaldosteronism type 2D, pseudohypoaldosteronism type 2A and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 3 |
|---|---|
| UniProt accession | Q9UH77 |
| Gene | KLHL3 |
| Organism | Homo sapiens |
| Length | 587 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (173)
Diseases linked to this target (Open Targets).
- pseudohypoaldosteronism type 2D · score 0.83
- pseudohypoaldosteronism type 2A · score 0.55
- hemoglobin measurement · score 0.43
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.34
- hematocrit · score 0.33
- cerebral palsy · score 0.27
- autosomal dominant pseudohypoaldosteronism type 1 · score 0.21
- age at menarche · score 0.20
- heart failure · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UH77-F1 | alphafold | PREDICTED | 90.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UH77.
Amino-acid sequence (587 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL3?
The strongest Open Targets associations for KLHL3 are pseudohypoaldosteronism type 2D, pseudohypoaldosteronism type 2A, hemoglobin measurement, neurodegenerative disease and genetic disorder.
How long is the KLHL3 protein?
The Homo sapiens KLHL3 protein (UniProt Q9UH77) is 587 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UH77 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UH77 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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