F-box only protein 40 (FBXO40)
Homo sapiens — UniProt Q9UH90
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 40 (FBXO40) is a protein from Homo sapiens identified by UniProt accession Q9UH90, 709 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9UH90; gene symbol FBXO40.
- Organism: Homo sapiens.
- Length: 709 amino acids.
- Top disease associations (Open Targets): mean platelet volume, clear cell renal carcinoma and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 40 |
|---|---|
| UniProt accession | Q9UH90 |
| Gene | FBXO40 |
| Organism | Homo sapiens |
| Length | 709 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.28
- clear cell renal carcinoma · score 0.18
- mean corpuscular volume · score 0.16
- mean reticulocyte volume · score 0.10
- asthma · score 0.10
- mean corpuscular hemoglobin concentration · score 0.07
- arterial stiffness measurement · score 0.05
- central nervous system cancer · score 0.04
- acute quadriplegic myopathy · score 0.01
- Duchenne muscular dystrophy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UH90-F1 | alphafold | PREDICTED | 73.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UH90.
Amino-acid sequence (709 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO40?
The strongest Open Targets associations for FBXO40 are mean platelet volume, clear cell renal carcinoma, mean corpuscular volume, mean reticulocyte volume and asthma.
How long is the FBXO40 protein?
The Homo sapiens FBXO40 protein (UniProt Q9UH90) is 709 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UH90 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UH90 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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