SUN domain-containing protein 2 (SUN2)
Homo sapiens — UniProt Q9UH99
Data last refreshed: (UniProt release unknown)
Key facts
SUN domain-containing protein 2 (SUN2) is a protein from Homo sapiens identified by UniProt accession Q9UH99, 717 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.
- UniProt accession: Q9UH99; gene symbol SUN2.
- Organism: Homo sapiens.
- Length: 717 amino acids.
- Top disease associations (Open Targets): mirror movements 3, head and neck squamous cell carcinoma and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SUN domain-containing protein 2 |
|---|---|
| UniProt accession | Q9UH99 |
| Gene | SUN2 |
| Organism | Homo sapiens |
| Length | 717 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- mirror movements 3 · score 0.33
- head and neck squamous cell carcinoma · score 0.23
- mathematical ability · score 0.22
- alkaline phosphatase measurement · score 0.21
- Emery-Dreifuss muscular dystrophy · score 0.20
- prostate carcinoma · score 0.19
- triglyceride measurement · score 0.17
- sleep duration · score 0.12
- resting heart rate · score 0.11
- HIV-1 infection · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UH99-F1 | alphafold | PREDICTED | 67.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UH99.
Amino-acid sequence (717 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SUN2?
The strongest Open Targets associations for SUN2 are mirror movements 3, head and neck squamous cell carcinoma, mathematical ability, alkaline phosphatase measurement and Emery-Dreifuss muscular dystrophy.
How long is the SUN2 protein?
The Homo sapiens SUN2 protein (UniProt Q9UH99) is 717 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UH99 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UH99 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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