LIM domain and actin-binding protein 1 (LIMA1)
Homo sapiens — UniProt Q9UHB6
Data last refreshed: (UniProt release unknown)
Key facts
LIM domain and actin-binding protein 1 (LIMA1) is a protein from Homo sapiens identified by UniProt accession Q9UHB6, 759 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q9UHB6; gene symbol LIMA1.
- Organism: Homo sapiens.
- Length: 759 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neutrophil count and myeloid white cell count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | LIM domain and actin-binding protein 1 |
|---|---|
| UniProt accession | Q9UHB6 |
| Gene | LIMA1 |
| Organism | Homo sapiens |
| Length | 759 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- neutrophil count · score 0.25
- myeloid white cell count · score 0.22
- colorectal cancer · score 0.19
- leukocyte count · score 0.16
- Immature Reticulocyte Fraction Measurement · score 0.14
- brain measurement · score 0.12
- glaucoma · score 0.11
- self reported educational attainment · score 0.10
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHB6-F1 | alphafold | PREDICTED | 51.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHB6.
Amino-acid sequence (759 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIMA1?
The strongest Open Targets associations for LIMA1 are neurodegenerative disease, neutrophil count, myeloid white cell count, colorectal cancer and leukocyte count.
How long is the LIMA1 protein?
The Homo sapiens LIMA1 protein (UniProt Q9UHB6) is 759 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHB6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHB6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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