Ubiquilin-2 (UBQLN2)
Homo sapiens — UniProt Q9UHD9
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquilin-2 (UBQLN2) is a protein from Homo sapiens identified by UniProt accession Q9UHD9, 624 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9UHD9; gene symbol UBQLN2.
- Organism: Homo sapiens.
- Length: 624 amino acids.
- Top disease associations (Open Targets): amyotrophic lateral sclerosis type 15, familial amyotrophic lateral sclerosis and amyotrophic lateral sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquilin-2 |
|---|---|
| UniProt accession | Q9UHD9 |
| Gene | UBQLN2 |
| Organism | Homo sapiens |
| Length | 624 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis type 15 · score 0.81
- familial amyotrophic lateral sclerosis · score 0.68
- amyotrophic lateral sclerosis · score 0.60
- Amyotrophic lateral sclerosis · score 0.38
- glioblastoma multiforme · score 0.23
- lung adenocarcinoma · score 0.19
- vascular dementia · score 0.11
- axial length measurement · score 0.11
- hepatocellular carcinoma · score 0.07
- esophageal squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHD9-F1 | alphafold | PREDICTED | 61.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHD9.
Amino-acid sequence (624 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBQLN2?
The strongest Open Targets associations for UBQLN2 are amyotrophic lateral sclerosis type 15, familial amyotrophic lateral sclerosis, amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis and glioblastoma multiforme.
How long is the UBQLN2 protein?
The Homo sapiens UBQLN2 protein (UniProt Q9UHD9) is 624 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.