N-acetyltransferase 8 (NAT8)
Homo sapiens — UniProt Q9UHE5
Data last refreshed: (UniProt release unknown)
Key facts
N-acetyltransferase 8 (NAT8) is a protein from Homo sapiens identified by UniProt accession Q9UHE5, 227 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q9UHE5; gene symbol NAT8.
- Organism: Homo sapiens.
- Length: 227 amino acids.
- Top disease associations (Open Targets): serum metabolite measurement, urinary metabolite measurement and blood metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetyltransferase 8 |
|---|---|
| UniProt accession | Q9UHE5 |
| Gene | NAT8 |
| Organism | Homo sapiens |
| Length | 227 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.46
- urinary metabolite measurement · score 0.46
- blood metabolite measurement · score 0.42
- creatinine measurement · score 0.36
- glomerular filtration rate · score 0.35
- hydroxy-leucine measurement · score 0.34
- primary ovarian insufficiency · score 0.34
- metabolite measurement · score 0.32
- cystatin C measurement · score 0.29
- n-acetyl neuraminic acid measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHE5-F1 | alphafold | PREDICTED | 91.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHE5.
Amino-acid sequence (227 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NAT8?
The strongest Open Targets associations for NAT8 are serum metabolite measurement, urinary metabolite measurement, blood metabolite measurement, creatinine measurement and glomerular filtration rate.
How long is the NAT8 protein?
The Homo sapiens NAT8 protein (UniProt Q9UHE5) is 227 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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