Tachykinin-3 (TAC3)
Homo sapiens — UniProt Q9UHF0
Data last refreshed: (UniProt release unknown)
Key facts
Tachykinin-3 (TAC3) is a protein from Homo sapiens identified by UniProt accession Q9UHF0, 121 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.
- UniProt accession: Q9UHF0; gene symbol TAC3.
- Organism: Homo sapiens.
- Length: 121 amino acids.
- Top disease associations (Open Targets): hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism and isolated congenital hypogonadotropic hypogonadism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tachykinin-3 |
|---|---|
| UniProt accession | Q9UHF0 |
| Gene | TAC3 |
| Organism | Homo sapiens |
| Length | 121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (236)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism · score 0.57
- Hypogonadotropic hypogonadism · score 0.51
- isolated congenital hypogonadotropic hypogonadism · score 0.46
- Kallmann syndrome · score 0.35
- Delayed puberty · score 0.33
- infertility · score 0.33
- ovarian cancer · score 0.26
- head and neck squamous cell carcinoma · score 0.16
- cutaneous melanoma · score 0.13
- neurofibrillary tangles measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHF0-F1 | alphafold | PREDICTED | 64.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHF0.
Amino-acid sequence (121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAC3?
The strongest Open Targets associations for TAC3 are hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism, isolated congenital hypogonadotropic hypogonadism, Kallmann syndrome and Delayed puberty.
How long is the TAC3 protein?
The Homo sapiens TAC3 protein (UniProt Q9UHF0) is 121 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHF0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHF0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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