Zinc finger transcription factor Trps1 (TRPS1)
Homo sapiens — UniProt Q9UHF7
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger transcription factor Trps1 (TRPS1) is a protein from Homo sapiens identified by UniProt accession Q9UHF7, 1281 residues long. MolForge cross-references it against 0 known binders and 501 disease associations.
- UniProt accession: Q9UHF7; gene symbol TRPS1.
- Organism: Homo sapiens.
- Length: 1281 amino acids.
- Top disease associations (Open Targets): Trichorhinophalangeal syndrome type 1 and 3, trichorhinophalangeal syndrome, type III and trichorhinophalangeal syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger transcription factor Trps1 |
|---|---|
| UniProt accession | Q9UHF7 |
| Gene | TRPS1 |
| Organism | Homo sapiens |
| Length | 1281 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (501)
Diseases linked to this target (Open Targets).
- Trichorhinophalangeal syndrome type 1 and 3 · score 0.81
- trichorhinophalangeal syndrome, type III · score 0.74
- trichorhinophalangeal syndrome · score 0.56
- genetic disorder · score 0.52
- heel bone mineral density · score 0.50
- lean body mass · score 0.48
- high density lipoprotein cholesterol measurement · score 0.48
- reticulocyte count · score 0.48
- total cholesterol measurement · score 0.48
- erythrocyte count · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHF7-F1 | alphafold | PREDICTED | 48.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHF7.
Amino-acid sequence (1281 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRPS1?
The strongest Open Targets associations for TRPS1 are Trichorhinophalangeal syndrome type 1 and 3, trichorhinophalangeal syndrome, type III, trichorhinophalangeal syndrome, genetic disorder and heel bone mineral density.
How long is the TRPS1 protein?
The Homo sapiens TRPS1 protein (UniProt Q9UHF7) is 1281 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHF7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHF7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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