Doublecortin domain-containing protein 2 (DCDC2)
Homo sapiens — UniProt Q9UHG0
Data last refreshed: (UniProt release unknown)
Key facts
Doublecortin domain-containing protein 2 (DCDC2) is a protein from Homo sapiens identified by UniProt accession Q9UHG0, 476 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.
- UniProt accession: Q9UHG0; gene symbol DCDC2.
- Organism: Homo sapiens.
- Length: 476 amino acids.
- Top disease associations (Open Targets): sclerosing cholangitis, Senior-Boichis syndrome and hearing loss, autosomal recessive.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Doublecortin domain-containing protein 2 |
|---|---|
| UniProt accession | Q9UHG0 |
| Gene | DCDC2 |
| Organism | Homo sapiens |
| Length | 476 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (95)
Diseases linked to this target (Open Targets).
- sclerosing cholangitis · score 0.77
- Senior-Boichis syndrome · score 0.68
- hearing loss, autosomal recessive · score 0.64
- deafness · score 0.54
- dyslexia · score 0.46
- creatinine measurement · score 0.42
- ciliopathy · score 0.38
- neurodegenerative disease · score 0.37
- glomerular filtration rate · score 0.37
- chylomicron retention disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHG0-F1 | alphafold | PREDICTED | 63.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHG0.
Amino-acid sequence (476 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCDC2?
The strongest Open Targets associations for DCDC2 are sclerosing cholangitis, Senior-Boichis syndrome, hearing loss, autosomal recessive, deafness and dyslexia.
How long is the DCDC2 protein?
The Homo sapiens DCDC2 protein (UniProt Q9UHG0) is 476 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHG0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHG0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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