ProSAAS (PCSK1N)
Homo sapiens — UniProt Q9UHG2
Data last refreshed: (UniProt release unknown)
Key facts
ProSAAS (PCSK1N) is a protein from Homo sapiens identified by UniProt accession Q9UHG2, 260 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.
- UniProt accession: Q9UHG2; gene symbol PCSK1N.
- Organism: Homo sapiens.
- Length: 260 amino acids.
- Top disease associations (Open Targets): Barrett's esophagus, neoplasm and Asperger syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ProSAAS |
|---|---|
| UniProt accession | Q9UHG2 |
| Gene | PCSK1N |
| Organism | Homo sapiens |
| Length | 260 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (151)
Diseases linked to this target (Open Targets).
- Barrett's esophagus · score 0.05
- neoplasm · score 0.05
- Asperger syndrome · score 0.05
- autism · score 0.04
- synucleinopathy · score 0.04
- N-acetylaspartate deficiency · score 0.04
- intellectual disability, autosomal recessive 58 · score 0.04
- autism spectrum disorder · score 0.03
- spinocerebellar ataxia type 27 · score 0.03
- 15q11q13 microduplication syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHG2-F1 | alphafold | PREDICTED | 58.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHG2.
Amino-acid sequence (260 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCSK1N?
The strongest Open Targets associations for PCSK1N are Barrett's esophagus, neoplasm, Asperger syndrome, autism and synucleinopathy.
How long is the PCSK1N protein?
The Homo sapiens PCSK1N protein (UniProt Q9UHG2) is 260 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHG2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHG2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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