Large neutral amino acids transporter small subunit 2 (SLC7A8)
Homo sapiens — UniProt Q9UHI5
Data last refreshed: (UniProt release unknown)
Key facts
Large neutral amino acids transporter small subunit 2 (SLC7A8) is a protein from Homo sapiens identified by UniProt accession Q9UHI5, 535 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.
- UniProt accession: Q9UHI5; gene symbol SLC7A8.
- Organism: Homo sapiens.
- Length: 535 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and Short stature.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large neutral amino acids transporter small subunit 2 |
|---|---|
| UniProt accession | Q9UHI5 |
| Gene | SLC7A8 |
| Organism | Homo sapiens |
| Length | 535 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neuroinflammatory disorder · score 0.33
- Short stature · score 0.32
- bone density · score 0.21
- urate measurement · score 0.21
- glioblastoma multiforme · score 0.18
- neuroticism measurement · score 0.18
- Red cell distribution width · score 0.16
- mean platelet volume · score 0.13
- deafness · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHI5-F1 | alphafold | PREDICTED | 82.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHI5.
Amino-acid sequence (535 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC7A8?
The strongest Open Targets associations for SLC7A8 are neurodegenerative disease, neuroinflammatory disorder, Short stature, bone density and urate measurement.
How long is the SLC7A8 protein?
The Homo sapiens SLC7A8 protein (UniProt Q9UHI5) is 535 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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