A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)
Homo sapiens — UniProt Q9UHI8
Data last refreshed: (UniProt release unknown)
Key facts
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is a protein from Homo sapiens identified by UniProt accession Q9UHI8, 967 residues long. MolForge cross-references it against 0 known binders and 333 disease associations.
- UniProt accession: Q9UHI8; gene symbol ADAMTS1.
- Organism: Homo sapiens.
- Length: 967 amino acids.
- Top disease associations (Open Targets): vital capacity, neurodegenerative disease and primary ovarian insufficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
|---|---|
| UniProt accession | Q9UHI8 |
| Gene | ADAMTS1 |
| Organism | Homo sapiens |
| Length | 967 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (333)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.41
- neurodegenerative disease · score 0.33
- primary ovarian insufficiency · score 0.27
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.23
- protein measurement · score 0.19
- hair colour measurement · score 0.19
- late-onset Alzheimers disease · score 0.18
- gastric adenocarcinoma · score 0.18
- neurofilament light chain measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHI8-F1 | alphafold | PREDICTED | 77.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHI8.
Amino-acid sequence (967 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTS1?
The strongest Open Targets associations for ADAMTS1 are vital capacity, neurodegenerative disease, primary ovarian insufficiency, breast adenocarcinoma and head and neck squamous cell carcinoma.
How long is the ADAMTS1 protein?
The Homo sapiens ADAMTS1 protein (UniProt Q9UHI8) is 967 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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