Sedoheptulokinase (SHPK)
Homo sapiens — UniProt Q9UHJ6
Data last refreshed: (UniProt release unknown)
Key facts
Sedoheptulokinase (SHPK) is a protein from Homo sapiens identified by UniProt accession Q9UHJ6, 478 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9UHJ6; gene symbol SHPK.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): cystinosis, isolated sedoheptulokinase deficiency and ocular cystinosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sedoheptulokinase |
|---|---|
| UniProt accession | Q9UHJ6 |
| Gene | SHPK |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- cystinosis · score 0.49
- isolated sedoheptulokinase deficiency · score 0.49
- ocular cystinosis · score 0.45
- nephropathic cystinosis · score 0.42
- Juvenile nephropathic cystinosis · score 0.33
- neurodegenerative disease · score 0.27
- Miyoshi myopathy · score 0.09
- neoplasm · score 0.07
- glioblastoma multiforme · score 0.05
- cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHJ6-F1 | alphafold | PREDICTED | 94.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHJ6.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHPK?
The strongest Open Targets associations for SHPK are cystinosis, isolated sedoheptulokinase deficiency, ocular cystinosis, nephropathic cystinosis and Juvenile nephropathic cystinosis.
How long is the SHPK protein?
The Homo sapiens SHPK protein (UniProt Q9UHJ6) is 478 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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