Acyltransferase PGAP2 (PGAP2)
Homo sapiens — UniProt Q9UHJ9
Data last refreshed: (UniProt release unknown)
Key facts
Acyltransferase PGAP2 (PGAP2) is a protein from Homo sapiens identified by UniProt accession Q9UHJ9, 254 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q9UHJ9; gene symbol PGAP2.
- Organism: Homo sapiens.
- Length: 254 amino acids.
- Top disease associations (Open Targets): hyperphosphatasia-intellectual disability syndrome, Intellectual disability and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyltransferase PGAP2 |
|---|---|
| UniProt accession | Q9UHJ9 |
| Gene | PGAP2 |
| Organism | Homo sapiens |
| Length | 254 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- hyperphosphatasia-intellectual disability syndrome · score 0.64
- Intellectual disability · score 0.60
- genetic disorder · score 0.34
- alkaline phosphatase measurement · score 0.29
- Hypoplasia of the corpus callosum · score 0.12
- Micrognathia · score 0.12
- mean corpuscular volume · score 0.07
- ankyloblepharon filiforme adnatum-cleft palate syndrome · score 0.06
- van der Woude syndrome · score 0.05
- IGF-1 measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHJ9-F1 | alphafold | PREDICTED | 90.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHJ9.
Amino-acid sequence (254 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PGAP2?
The strongest Open Targets associations for PGAP2 are hyperphosphatasia-intellectual disability syndrome, Intellectual disability, genetic disorder, alkaline phosphatase measurement and Hypoplasia of the corpus callosum.
How long is the PGAP2 protein?
The Homo sapiens PGAP2 protein (UniProt Q9UHJ9) is 254 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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