FMR1-interacting protein NUFIP1 (NUFIP1)
Homo sapiens — UniProt Q9UHK0
Data last refreshed: (UniProt release unknown)
Key facts
FMR1-interacting protein NUFIP1 (NUFIP1) is a protein from Homo sapiens identified by UniProt accession Q9UHK0, 495 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9UHK0; gene symbol NUFIP1.
- Organism: Homo sapiens.
- Length: 495 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, high density lipoprotein cholesterol measurement and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FMR1-interacting protein NUFIP1 |
|---|---|
| UniProt accession | Q9UHK0 |
| Gene | NUFIP1 |
| Organism | Homo sapiens |
| Length | 495 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- high density lipoprotein cholesterol measurement · score 0.37
- reticulocyte count · score 0.29
- apolipoprotein A 1 measurement · score 0.28
- IGF-1 measurement · score 0.22
- lymphocyte count · score 0.20
- reticulocyte measurement · score 0.13
- psoriasis · score 0.10
- Immature Reticulocyte Fraction Measurement · score 0.08
- Abnormality of refraction · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHK0-F1 | alphafold | PREDICTED | 55.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHK0.
Amino-acid sequence (495 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUFIP1?
The strongest Open Targets associations for NUFIP1 are neurodegenerative disease, high density lipoprotein cholesterol measurement, reticulocyte count, apolipoprotein A 1 measurement and IGF-1 measurement.
How long is the NUFIP1 protein?
The Homo sapiens NUFIP1 protein (UniProt Q9UHK0) is 495 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHK0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHK0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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