Alpha-methylacyl-CoA racemase (AMACR)
Homo sapiens — UniProt Q9UHK6
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-methylacyl-CoA racemase (AMACR) is a protein from Homo sapiens identified by UniProt accession Q9UHK6, 382 residues long. MolForge cross-references it against 0 known binders and 246 disease associations.
- UniProt accession: Q9UHK6; gene symbol AMACR.
- Organism: Homo sapiens.
- Length: 382 amino acids.
- Top disease associations (Open Targets): Alpha-methylacyl-CoA racemase deficiency, Congenital bile acid synthesis defect type 4 and congenital bile acid synthesis defect 4.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-methylacyl-CoA racemase |
|---|---|
| UniProt accession | Q9UHK6 |
| Gene | AMACR |
| Organism | Homo sapiens |
| Length | 382 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (246)
Diseases linked to this target (Open Targets).
- Alpha-methylacyl-CoA racemase deficiency · score 0.74
- Congenital bile acid synthesis defect type 4 · score 0.69
- congenital bile acid synthesis defect 4 · score 0.57
- genetic disorder · score 0.41
- retinitis pigmentosa · score 0.37
- BMI-adjusted waist-hip ratio · score 0.25
- low grade glioma · score 0.18
- blood protein measurement · score 0.17
- waist-hip ratio · score 0.12
- spastic ataxia · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHK6-F1 | alphafold | PREDICTED | 95.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHK6.
Amino-acid sequence (382 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMACR?
The strongest Open Targets associations for AMACR are Alpha-methylacyl-CoA racemase deficiency, Congenital bile acid synthesis defect type 4, congenital bile acid synthesis defect 4, genetic disorder and retinitis pigmentosa.
How long is the AMACR protein?
The Homo sapiens AMACR protein (UniProt Q9UHK6) is 382 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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